浅谈肝俞龙虎交战针法为主治疗排卵障碍性不孕

结合中医理论及外界影响因素分析认为,排卵障碍性不孕以"肝气郁结、疏泄失调"为病机,治则立"疏肝解郁、调畅气机"为大法,探讨治疗该病选用肝俞施用龙虎交战针法的理论依据。为针灸治疗排卵障碍性不孕提供新的思路及方法,同时也体现了古典针法创新性的运用。     

手术室心理护理对手术患者精神状态的影响

目的探讨手术室心理护理对手术患者焦虑、抑郁状态及护理满意度的影响。方法以医院2017年1月—2019年4月在医院接受手术治疗的1200例患者展开研究,随机将其划分为研究组(n=600)与对照组(n=600),分别接受常规基础上的心理护理以及单纯常规护理,对比分析患者抑郁、焦虑评分、护理满意度。结果治疗后,与对照组比,观察组抑郁、焦虑评分均更低;且研究组(97.0%)患者护理满意度高于对照组(83.7%),差异有统计学意义(P<0.05)。结论心理护理干预对于手术患者精神干预结果比较好,不仅可以改善患者的抑郁、焦虑情况,也能提升其护理满意度。     

民航飞行学员飞行训练应激源研究

目的确定我国民航飞行学员飞行训练的应激源。方法采用德尔菲法形成量表初步维度并在此基础上编制初测量表,从不同训练分院及国外训练归校的学员中采取分层随机取样;选取524名飞行学员进行测试,对所得数据进行分析形成正式问卷。对所获数据进行探索性因素分析和验证性因素分析,并分别检验量表的内部一致性系数、重测信度、内容效度与结构效度。结果训练环境、职业前景、飞行教员、座舱环境4个维度共解释了总变异的57.154%。量表总体的Cronbach’sα系数为0.830,各因子的Cronbach’sα系数为0.751~0.782,重测的相关系数均在0.806(P<0.01)以上。维度间的相关系数为0.134~0.438(P<0.05),各维度与总体的相关系数在0.617~0.748(P<0.01)。一阶4因素模型(GFI=0.929、IFI=0.989、TLI=0.986、CFI=0.989、RMSEA=0.013)拟合效果较好。结论民航飞行学员飞行训练应激源量表符合心理测量学标准,具有良好信效度,民航飞行学员飞行训练应激源主要来源于训练环境、职业前景、飞行教员、座舱环境。     

自我效能感在女性尿失禁患者中社会支持与抑郁之间的调节作用

目的 探讨自我效能感在女性尿失禁患者社会支持与抑郁之间调节作用,为降低尿失禁患者的抑郁水平提供参考。方法 选取2016年9月1日—2018年12月31日期间在三门峡市中心医院妇科诊断为尿失禁的患者作为本次的研究对象进行问卷调查,调查内容包括社会人口学资料、抑郁自评量表、一般自我效能感量表以及领悟社会支持评定量表等。结果 225例研究对象中,检出抑郁症状72例(32.0%),高龄、病程长、肥胖、离婚和丧偶、有抑郁家族史的患者抑郁检出率更高,差异有统计学意义(P<0.05);抑郁平均得分48.38.2,领悟社会支持平均得分为59.58.7,自我效能感平均得分为22.16.3;领悟社会支持(β=-0.251,P=0.002)和自我效能感(β=-0.324,P<0.001)对抑郁均呈负向作用,P<0.001),自我效能感在尿失禁患者社会支持与抑郁之间的关系中存在增强型调节作用(β=-0.114,P=0.020)。结论 女性尿失禁患者中抑郁检出率高,在提高其社会支持的前提下,同时提高自我效能,可进一步降低患者抑郁水平。     

柴胡加龙骨牡蛎汤联合腹针治疗脑卒中后抑郁疗效观察

目的:观察柴胡加龙骨牡蛎汤联合腹针治疗脑卒中后抑郁的临床疗效。方法:将94例失眠患者随机分为对照组和治疗组各47例,对照组采用氟哌噻吨美利曲辛片治疗,治疗组采用柴胡加龙骨牡蛎汤联合腹针治疗,两组均连续治疗6周后判定临床疗效,比较两组患者治疗前后汉密尔顿抑郁量表(HAMD)评分及Barthel指数(BI)变化。结果:两组患者治疗后HAMD评分较本组治疗前明显降低(P<0.05),BI评分较治疗前明显升高(P<0.05),且治疗组治疗后HAMD评分低于对照组(P<0.05),BI评分高于对照组(P<0.05)。两组患者治疗后中医证候积分与治疗前比较,差异有统计学意义(P<0.05);两组患者中医证候积分差值比较,差异有统计学意义(P<0.05)。结论:柴胡加龙骨牡蛎汤联合腹针治疗脑卒中后抑郁可改善患者抑郁症状。     

Vasogenic edema versus neuroplasticity as neural correlates of hippocampal volume increase following electroconvulsive therapy

BackgroundVolume increases of the hippocampus after electroconvulsive therapy (ECT) are a robust finding, pointing into the direction of neurogenesis. However, such volumetric increases could also be explained by edema and/or neuroplastic changes (such as angiogenesis).ObjectivesIf edema explains the volume increase of the hippocampus we hypothesize it would lead to increased mean diffusivity (MD). If neuroplastic would explain the volume increase, it would lead to decreased MD. To investigate angiogenesis as explanation we studied the perfusion fraction f and the pseudodiffusion component D1 obtained from intravoxel incoherent motion (IVIM) data, and relative perfusion changes obtained from arterial spin labelling (ASL) data.MethodsUsing ultra-high field (7 tesla) MRI we acquired IVIM and ASL data. We compared MD, f, D1 and ASL values for both hippocampi in 21 patients (before and after 10 ECT sessions) and 8 healthy controls (without ECT) in a linear mixed model adjusting for age and gender.ResultsWe found a significant decrease in MD (which was absent in the healthy controls) in the left and right hippocampus (t = -3.98, p < 0.001). In addition, a decrease in f (t = -4.61, p < 0.001, but not in controls) and no differences in D1 or ASL perfusion values (both p > 0.05) were found.ConclusionsThe decrease in MD in perfusion fraction f suggest that formation of edema nor angiogenesis are responsible for the ECT-induced volume increases in the hippocampus. Also, it supports the hypothesis that hippocampal volume increases might be due to neuroplastic changes.     

Intermittent theta-burst stimulation moderates interaction between increment of N-Acetyl-Aspartate in anterior cingulate and improvement of unipolar depression

BackgroundIntermittent theta-burst stimulation (iTBS), a novel repetitive transcranial magnetic stimulation (rTMS) technique, appears to have antidepressant effects when applied over left dorsolateral prefrontal cortex (DLPFC). However, its underlying neurobiological mechanisms are unclear. Proton magnetic resonance spectroscopy (¹H-MRS) provides in vivo measurements of cerebral metabolites altered in major depressive disorder (MDD) like N-acetyl-aspartate (NAA) and choline-containing compounds (Cho). We used MRS to analyse effects of iTBS on the associations between the shifts in the NAA and Cho levels during therapy and MDD improvement.MethodsIn-patients with unipolar MDD (N = 57), in addition to treatment as usual, were randomized to receive 20 iTBS or sham stimulations applied over left DLPFC over four weeks. Single-voxel ¹H-MRS of the anterior cingulate cortex (ACC) was performed at baseline and follow-up. Increments of concentrations, as well as MDD improvement, were defined as endpoints. We tested a moderated mediation model of effects using the PROCESS macro (an observed variable ordinary least squares and logistic regression path analysis modeling tool) for SPSS.ResultsImprovement of depressive symptoms was significantly associated with decrease of Cho/NAA ratio, mediated by NAA. iTBS had a significant moderating effect enhancing the relationship between NAA change and depression improvement.ConclusionsOur findings suggest a potential neurochemical pathway and mechanisms of antidepressant action of iTBS, which may moderate the improvement of metabolic markers of neuronal viability. iTBS might increase neuroplasticity, thus facilitating normalization of neuronal circuit function.